BCHM 658 Lecture Notes - Lecture 4: Cytotoxic T Cell, B-Cell Receptor, Mhc Class Ii
Document Summary
Speed, specificity, memory: compare the ways in which dendritic cells, b cells and t cells recognize foreign antigens. Dc"s express innate receptors for pamps, non-mammalian molecules, danger signals. Prrs are proteins expressed by cells of the innate immune system that identify pattern-associated molecular patterns (pamps) associated with microbial pathogens, or cellular stress. Prrs include the large family of membrane bound toll-like receptors and cytoplasmic nod-like receptors; the latter can promote attachment, engulfment and destruction of bacteria by phagocytes. B cells: b cell receptor complex recognizes physico-chemical properties of surface accessible antigens. Any molecular composition (protein, carbohydrate, electrostatically chanrged molecules etc) can be recognized by the b cell receptor. T cells: t cell receptor is a cell surface heterodimeric protein with a variable region derived by gene rearrangement that is capable of recognizing peptide when it is presented by mhc. T cells can recognize processed and presented peptide antigens that might be embedded in the pathogen.
