BMS 501 Lecture Notes - Lecture 10: Chromosome, Plasmid, Hfr Cell
9 May 2016
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*** be able to identify mutations: insertion- adding one or more bases, deletion- removing one or more bases, inversion- a dna sequence is flipped in orientation. Sometimes use this to regulate genes: informational classes of mutation: How changes at the dna level affect the coding of a protein. Silent- change in dna doesn"t affect the amino acid sequence. Third position, not that important, wobble position". If it changes it doesn"t always change the protein. Missense-change the amino acid sequence of the resulting protein. Nonsense- changes amino acid sequence to a stop codon. Shift-changes the opening reading frame of the gene. Result of the addition/ subtraction of a base. Shifts the bases forward/ backward with the addition/subtraction of a base if you subtracted/ add an amino acid (multiple of 3) from the sequence, it is usually not a frame-shift mutation. Point- change a single nucleotide: all occur naturally.
