BIOL 1119 Lecture Notes - Lecture 4: Vasodilation, Vasoconstriction, Angiogenesis
3 Oct 2017
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Document Summary
Control of blood pressure/flow: regulation of blood pressure/flow. Local control of bp and flow: three ways to regulate bp and blood flow through vasomotion local, neural and hormonal regulation of vasomotion. Arteriolar smooth muscle has spontaneous contractile activity (intrinsic or basal tone): independent of local, neural or hormonal input. External signals affect smooth muscle baseline level of contraction: classic flow autoregulation. Changes in bp lead to local changes in blood flow. Mechanism of local chemical changes causes local resistance changes. Myogenic response: effect of stretch of smooth muscle in arteriole on smooth muscle constriction: active hyperemia or metabolic autoregulation. Substances that stimulate vasodilation: histamine, prostagladins, bradykinins.
