BIOL 1119 Lecture Notes - Lecture 4: Pressure Gradient, Oncotic Pressure, Perfusion

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Edema is accumulation of excess liquid in tissue (swelling in face, fingers, ankles, abdomen) Three fundamental causes: increased filtration, reduced reabsorption and blockage of lymph. One important cause of increased filtration is failure of the ventricles. Failure of the right ventricle: cause blood to back up in right atrium: slows down return of blood from body, pressure builds up in systemic capillaries with increased fluid forced into systemic tissues: systemic edema. Failure of the left ventricle: cause blood to back up in left atrium: slows down the return of blood from the lungs, pressure builds up in pulmonary capillaries with increased fluid forced into lung tissues: pulmonary edema. Systemic edema could cause circulatory shock: too much fluid may move into tissue spaces: lowers blood volume causing bp to decrease. Increasing blood volume increases both pressure gradient and rate of venous return: widespread vasoconstriction: raises bp: increases the pressure and rate of venous return.

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