BIOL 1119 Lecture Notes - Lecture 2: Complement Membrane Attack Complex, Tumor Necrosis Factor Alpha, C3B
3 Oct 2017
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Document Summary
Spleen: helps stabilize blood volume by transferring excess plasma to the lymphatic system no dendritic cells, yes macrophages and lymphocytes. Nonspecific immune defenses: autocrine messenger- self effect; paracrine messenger- local effect. Antimicrobial proteins: interferons: cytokines which nonspecifically inhibit viral replication in host cells (two main types, secreted by cells invaded by viruses. Type i diffuse to neighboring cells and stimulate them to produce antiviral proteins, which interfere with viral replication in those cells. Interferons alert neighboring cells by binding to surface receptors in nearby cell: activate 2nd messenger system that stimulates those cells to make various kinds of anti-viral proteins. Type ii enhance natural killer cells and macrophage action: to destroy viral infected host cells and kill bacteria. Type ii strengthens the action of type i. Type ii attract wbcs to injury site. Antimicrobial proteins: complement system: complement system: a group of 30 or more proteins that contribute nonspecific immune and specific immune responses.
