BIOL 1400 Lecture Notes - Lecture 5: Riboflavin, Electron Transport Chain, Thermogenin
Document Summary
Coa is fed into a cyclic pathway called the tca cycle, where the substrate is oxidized and its energy conserved. Krebs cycle, founded by british biochemist hans krebs, who worked out the pathway in the. Condensation of the two-carbon acetyl group with a four-carbon oxaloacetate to form a six- carbon citrate molecule. During the cycle, the citrate molecule is decreased in chain length, one carbon at a time, regenerating the four-carbon oxaloacetate molecule, which can condense with another acetyl. Three of the reactions reduce nad+ to nadh, and one reaction reduces fad to fadh2. High-energy electrons are passed from fadh2 or nadh to the first of a series of electron carriers that make up the electron-transport chain, which is located in the inner mitochondrial membrane. Electrons pass along the electron-transport chain in energy-releasing reactions. The controlled movement of protons back across the membrane through an atp synthesizing enzyme provides the energy required to phosphorylate adp to atp.
