BIOL 2400 Lecture Notes - Lecture 9: Selman Waksman, Ernest Duchesne, African Trypanosomiasis
Document Summary
1904 - developed concept of selective toxicity and effectively treated african sleeping sickness. 1896 - first discovered penicillin but was lost. 1939 - demonstrated effectiveness of penicillin and won nobel prize. 1944 - discovered streptomycin and won nobel prize ability of drug to kill or inhibit pathogen while damaging host as little as possible. Define selective toxicity grug level required for clinical treatment. Define therapeutic dose drug level at which drug becomes too toxic for patient. Define toxic dose ratio of toxic dose to therapeutic dose. Define therapeutic index undesireable effects of drugs on host cells. Define side effects attack only a few different pathogens. Is penicillin static or cidal? lowest concentration of drug that inhibits growth of pathogen. Define minimal inhibitory concentration (mic) lowest concentration of drug that kills pathogen. Define minimal lethal concentration (mlc) innoculate media with dif concentrations of drug and plate with lowest concentration that showed no growth is mic.
