BIO 203 Lecture Notes - Lecture 17: Cancer, Dysplasia, Angiogenesis

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Outline
Uncontrolled cell division
Development of cancer
Multiple mutations
Cancer and epigenomics
Reducing the risk of cancer
Uncontrolled cell division
All forms of cancer share one characteristic: uncontrolled cell division
One in three people in the US will develop cancer
Tumor (neoplasm)=a new and abnormal growth of cells
Two basic types
Benign
Malignant
Benign tumors
Abnormal mass of tissue surrounded by a capsule of connective
tissue
Usually remains at the site where it forms
Often can be removed completely by surgery
Malignant tumor
Invades surrounding tissue
Spreads to multiple locations=metastsis
Cancerous
Stages of cancer development
Dysplasia in tissues of precancerous cells
Carcinoma in situ
Development of blood vessels-angiogenesis
Metastasis
1. Dysplasia
Precancerous cells look different from normal cells
Abnormal shape caused by ragged edges
Unusually large nuclei with odd shape
May have extra chromosomes or be missing parts of some chromosomes
Form a disorganized clump
2. Carcinoma in situ (“cancer in place”)
Tiny mass only a millimeter or two in diameter
3. Tumor attracts a blood supply- angiogenesis
Blood brings nutrients and carries away wastes, allowing continued growth
Vessels form an escape route for tumor cells
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