NURS 225 Lecture Notes - Lecture 15: Complement Membrane Attack Complex, Endothelium, Haemodynamic Response
Document Summary
Rubor (redness), tumor (swelling), pain, heat, loss of function. Initial vasoconstriction, then local vasodilation, (causes heat and redness), vascular endothelium becomes more permeable via histamine release, which lets fluids into the tissue space which also includes cells such as monocytes and macrophages. Inside the vessel i more blood components (rbc and platelets, etc. ) that results in increased likelihood of clotting. Immediate transient response: minor injury, quick, short duration. Immediate sustained response: response is immediate, but lasts longer. Thought to be caused by direct damage of endothelial cells. Neutrophils: first responders, secrete substances to kill, may recruit immature neutrophils if there is a lot, short life span. Monocytes/ macrophages: long life span, can last weeks at site. (cid:1688)garbage men(cid:1689). Come if the debris is too much for neutrophils to handle. Eosinophils: focus in parasitic infections and release chemical mediators. Basophils: allergic reactions, bind to ige to release histamine.
