NROSCI 0081 Lecture Notes - Lecture 13: Neurotransmitter Receptor, Functional Response, Autoreceptor
16 Feb 2018
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Efficacy: the ability of a drug-receptor complex to produce the maximum response. Additional doses produce no additional effect (plateau) Ability of a drug-receptor complex to produce a functional response. Find peak point on curve (higher y-axis number = higher efficacy) Affinity: measure of the ability of the drug to bind to its molecular target. The extent to which the ligand or drug is capable of binding and remained bound to receptor. High affinity: the ligand binds well and remains bound long enough to activate the receptor: more likely to have an effect or have an effect for a longer amount of time. Low affinity: ligand binds less well and may not remain bound long enough to activate the receptor. Potency: refers to the absolute number of drug molecules required to elicit a response (mg) Defined by its effective concentration (ec) = ec50 value. Concentration of agonist needed to elicit half of the maximum biological response of the agonist.
