BMS 300 Lecture Notes - Lecture 4: Peroxidase, Metabolic Acidosis, Malic Acid

• School: Quinnipiac University
• Department: Biomedical Sciences
• Course: BMS 300
• Professor: Thomas Martin

Document Summary

Inhibited by glucagon and epinephrine: allosteric activation, high atp levels, high levels of g-6-p, glycogenolysis, breakdown of glycogen, stimulate by, glucagon, epinephrine (major one during exercise), muscle contraction. Insulin promotes: glycogenolysis (increase blood glucose levels) Insulin inhibits: glucagon and epi/nor promotes, gluconeogenesis (increase blood glucose levels) Insulin: functions, increase glucose transport into cells, increase glycogenesis, increase fat storage (lipogenesis, increase protein synthesis, secreted when high levels of plasma glucose and amino acids. Inhibited by: glucagon (antagonist, sympathetic nervous system (epi/nor, glucagon, function, prevent hypoglycemia, increase glycogenolysis, increase gluconeogenesis, secreted when, low levels of plasma glucose, increased input from the sympathetic nervous system (epi/nor) Inhibited by insulin: lactate as an energy source, cori cycle and lactate shuttle, see diagrams. Initiate glycogenolysis and gluconeogenesis: both further increase hyperglycemia, glucosuria/ polyuria/ osmotic diuresis, dehydration, polydipsia, metabolic acidosis, ketoacidosis, neuropathy, retinopathy, renal failure, atherosclerosis, foot ulcers, treatment: insulin therapy, type 2- known as insulin-resistant diabetes.