11:115:301 Lecture Notes - Lecture 15: Isocitrate Lyase, Malate Dehydrogenase, Glyoxylic Acid

• School: Rutgers University
• Department: Biochemistry
• Course: 11:115:301
• Professor: Murphy

Document Summary

Plants with fatty seeds + some microorganisms have it. Glyoxylate short circuit of the cac in seedlings. Combines the 2c from 2 acetyl coa net synthesis of succinate. Can"t make sugar out of fatty acids. Sugar can make you fat, but fat can"t make you sweet! Some plants + microorganisms with the glyoxylate cycle can do net conversion of fats to glucose. Succinate oaa in the citric acid cycle. Take oaa to make glucose shut down cac no atp. Oxaloacetate + accoa + h2o --citrate synthase--> citrate + coa --aconitase--> cis-aconitate --aconitate--> isocitrate --isocitrate lyase--> succinate + Glyoxylate + accoa + h2o--malate synthase--> malate + coa. Malate + nad+ --malate dehydrogenase--> oxaloacetate + nadh + h+ Then supply us with the atp we need. Drives formation of a proton gradient through membrane to get more protons outside the inner membrane making the outside positively charged. Phosphorylation accomplished by rotary nanomachine racker"s knob or.