01:146:328 Lecture Notes - Lecture 20: Amastigote, Trypanosomatida, Lutzomyia
27 Dec 2018
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Leishmaniasis disease: about 30 different spp infect wide range of hosts (rodents, dogs, cats, etc, human infection ~ 21 spp, reservoir hosts, wild and domestic dogs and rodents. ~ 350 million at risk: 2 morphological forms. Spherical form, no flagellum, basal body kinetoplast, nucleus, surrounded by plasma membrane. Live inside macrophages we would expect these cells would destroy them but they don"t. Promastigotes figure 6. 3: substrate level phosphorylation produces little atp. Circular, elongated, has flagellum, more developed mitochondrion, nucleus. Amastigotes would live inside humans: oxidative phosphorylation a lot of atp, life cycle figure 6. 8. Old world (north africa, asia, europe) genus phlebotomus. Inside human: tip of promastigote attaches to surface of a macrophage, 2 ligands on promastigote, phosphoglycan, gp63 zinc metalloprotease. Visceral leishmaniasis: treatment in all spp. Leishmania mexicana new world: life cycle. Vector sand fly bites promastigotes in skin: macrophages engulf promastigotes, nodule on skin forms, ulcerates, amastigotes are in the ulcer/sore, erupts.
