01:377:370 Lecture Notes - Lecture 2: Myosin Light Chain, Sliding Filament Theory, Mitochondrial Biogenesis

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Tendons- connective tissue connecting muscle to periosteum of bone. Sarcolemma- muscle cell membrane that encloses fiber"s cellular contents. Satellite cells- myogenic stem cells located within the sarcolemma: help regenerative cell growth and repair of muscle cell, role in hypertrophy. Apoptosis- send out signals for cell death. 2:1 filament ratio: includes several other structural and functional proteins (titin/nebulin) Skeletal muscle has rich vascular network to supply oxygen and nutrient demands during exercise. Rhythmic flow: blood vessels run through perimysium, vessels compressed during contraction phase, vessels open during relaxation phase, over 60% force-generating capacity, elevated intramuscular pressure occludes local blood flow. Training enhances capillarization (especially endurance: expedites removal of metabolic by-products and heat, increases oxygen delivery, gets rid of carbon dioxide. Primary reason anaerobic processes supply atp (no oxygen supply) Fibrils- smaller functional units of fibers that contain myofilaments actin and myosin. Skeletal muscle ultra-structure: troponin and tropomyosin, several other structural proteins, runs from z disk to z disk.

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