01:830:331 Lecture Notes - Lecture 6: Axoplasmic Transport, Axon Terminal, Extracellular Fluid

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~synaptic transmission one neuron sending a message to the other through a synapse. ~terminal button of one neuron releases neurotransmitters which go to other neuron. ~presynaptic membrane is at the terminal button of the cell releasing neurotransmitters. ~synaptic cleft is the gap between the two neuron membranes, has extracellular fluid through which neurotransmitters diffuse. ~neurotransmitter attaches to binding site of a receptor molecule on postsynaptic membrane. ~synapse can occur on dendrite or axon or soma, but dendritic is commonly studied. ~release zone is the zone near the end of the terminal button, from where vesicles are released. ~small synaptic vesicles are made in golgi, carried to button by axoplasmic transport. ~large synaptic vesicles are made in soma, carried to button by axoplasmic transport. ~postsynaptic density visible density made of receptors for neurotransmitters. ~when action potential reaches terminal button, the synaptic vesicles fuse with the membrane of the terminal button and release their neurotransmitters into the extracellular fluid.

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