01:830:331 Lecture Notes - Lecture 20: Neurotransmitter Receptor, Psychopharmacology, Autoreceptor
24 Jul 2016
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~psychopharmacology studies effects of chemicals on nervous system/behavior. ~drug defined as an exogenous chemical that is not normally needed and affects cellular function. ~antagonist a drug that inhibits the effect of nt on the postsynaptic cell. ~agonist drug that promotes effects of nt on postsynaptic cell. ~another classification for drugs that interact with postsynaptic receptors: ~direct drug mimics neurotransmitter, attaches at the nt binding site, competitive binding. ~indirect drug attaches to an allosteric site and affects receptor, noncompetitive binding. They both have the same end result, but through different means. ~different ways a drug can be an agonist: The precursor molecule for the nt can be the agonist, so it stimulates production of nt. An agonist can bind with the protein that allows the vesicle of nt to be released into the synaptic cleft and stimulate it to work better and release more nt. A drug can be a direct agonist and bind at the postsynaptic receptor and mimic nt.
