01:830:340 Lecture Notes - Lecture 9: Grey Matter, Cognitive Behavioral Therapy, Psychiatric Rehabilitation
20 Mar 2017
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Document Summary
95% history of behavioral, social and psychiatric disturbances prior to the onset of psychosis. Developmental precursors: speech, motor development, movement abnormalities, unusual thought content, suspicion, substance abuse. Obsessive behaviors: active manifestations, distortions of normal behavior, exaggerations or excesses, delusions. Sensory experience in absence of environmental stimuli or input: can involve all senses. Absence or insufficiency of normal behavior: symptom cluster: Social withdrawal: slowed thinking, slowed speech, slowed movement, indifference to social contact, disorganized symptoms. Viral infection theory pregnant women exposed to flu virus in 1st or 2nd trimester. Parental age men who father children in advanced age more schizophrenic children. Impaired neural connections not apparent until 15-20yr. Increased cortisol in adolescence causes increased dopamine. Dopamine theory drugs that block dopamine decrease positive symptoms and disorganized symptoms. Dopamine is underactive in the prefrontal cortex unable to control da in the mesolimbic area giving rise to negative symptoms. Amphetamines amplify dopamine activity produce schizophrenic behavior.
