01:830:364 Lecture Notes - Lecture 5: Acetaldehyde, Alcoholism, Generalized Anxiety Disorder
Document Summary
Often in the form of a poorly controlled, positive-feedback loop. Unable to put an end to an ongoing drinking episode. Highly elevated bal (blood alcohol levels) are achieved during binge/blackout drinking episodes. During blackout drinking episodes, memory formation mechanisms are disabled. You can"t remember because you never made the memories in the first place. Genetic vulnerability to alcohol use disorder is highest in individuals who have low levels of alcohol dehydrogenase and high levels of acetylaldehyde. Genetic vulnerability to alcohol use disorder is lowest in individuals who have high levels of alcohol dehydrogenase and low levels of acetylaldehyde. These individuals with a low ratio of: Are unlikely to experience the cns effects of alc. With no family history of alcoholism, the risk of developing alcohol abuse problems is about 10% for men and 5% for women. For men with a first-degree relative (child, sibling, parent) who is an alcoholic, the risk for developing alcohol abuse problems goes up to 20%.
