ENS 332 Lecture Notes - Lecture 19: Macrophage, Histology, Immunoglobulin G

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Prevalence: a little bit more prevalent in women, 14% of us adults > 25yr old, 34% of us adults > 65yr old, total: ~26 million us adults. More common in women, with strong age effect: + strong evidence for risk, (+) weak evidence for risk, - strong evidence for protection. November 28, 2016: (-) weak evidence for protection, dip = distal interphalangeal joint last knuckle. Incidence: hand oa = 100 per 100,000 people per year, hip oa = 88 per 100,000 people per year, knee oa = 240 per 100,000 people per year. Hospitalizations: up to 3 million hospitalizations for oa in the us, ~90% of knee-replacement hospitalization/procedures are due to oa. Along with age, bmi is a strong predictor of serious oa and knee replacement. Rate of knee replacement rising rapidly in last few decades: ~50% of hip-replacement hospitalization/procedures are due to oa, strong age effect. Women are worse off than men e e n.

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