PHSL 310 Lecture Notes - Lecture 4: Lipid Bilayer, Lipid Raft, X-Ray Crystallography
Document Summary
Compartmentalization, scaffold for biochemical activities, selectively permeable barrier, transport of solutes, Responds to external stimuli, intercellular interaction, energy transduction. Ernst overton first insights into chemical nature of outer boundary layer of cell: discovered that the more lipid soluble the solute, the faster it could enter root cell hairs. E-gorter and f. grendel proposed that cellular membranes might contain a lipid bilayer: extracted bilayer from rbc"s and measured the sa that lipid would cover when spread over water concluded that plasma membrane had a bilayer. Davson and daniellie: found that there was an outer and inner protein layer, and the bilayer was penetrated by protein pores for solutes and ions to enter. Lipids are amphipathic: hydrophilic/hydrophobic regions: three main types: phosphoglycerides, sphingolipids, cholesterol. Phosphoglycerides: lipids have a phosphate group phospholipids. Sphingolipids: derivate of sphingosine an amino alcohol that contains a long hydrocarbon chain: has a ceramide, sphingomyelin, glycolipid, cerebroside, ganglioside.
