PSYC 302 Lecture Notes - Lecture 4: Helicobacter Pylori, Gastric Mucosa, Firmicutes
Document Summary
Infection: microorganism is established and growing in host (whether or not it is harmed) Important: developing biomarkers to predict predisposition for diseases, designing targeted therapies, personalized drug therapies/probiotics. 24. 3 oral cavity and airways: complex, heterogeneous microbial environment. 24. 5 skin microbiota: 1 mil bacteria per square cm of skin= total 1010 microorganisms, skin varies in chemical composition and moisture and can be, dry, moist or sebaceous. Influenced by environmental factors (weather), host factors (age/hygiene), etc. 24. 6 experiments: human microbiome project: survey of medical students to determine baseline for healthy human microbiomes. 24. 9 oral, skin and vaginal microbiota: dental caries and periodontitis, dental plaque: biofilm which has streptococcus/other fermenting bacteria, produce acid, wears down tooth enamel, periodontal disease thought to cause cardiovascular/arthritis. 24. 10 antibiotics: oral antibiotics decrease all microbes in human gut (target/non-target, use of antibiotics during first few months of life increases ibd risk/others related to dysbiosis.
