NRSC 335 Lecture 24: psychopathology - schizophrenia, depression and OCD

• School: Texas A&M University
• Department: Neuroscience
• Course: NRSC 335
• Professor: Stephen Maren

Document Summary

P a ra noia: biza rre dis turba nce s in thought, gra ndios e de lus ions, auditory ha llucina tions, emotiona l cha nge s. 60% concorda nce in monozygotic: both twins ha ve it. P et indica te s re duce d blood flow in fronta l corte x: during ta s ks tha t norma lly a ctiva te the fronta l corte x in controls. For a ll pa thology, ca us e a nd e ffe ct: dopa mine hypothe s is. S chizophre nia re s ults from too much dopa mine in the ba s a l ga nglia. In the 50s , it wa s dis cove re d tha t a dopa mine a nta gonis t (chlorproma zine , thora zine ) ha d a nti- ps ychotic prope rtie s.