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NRSC 335 (24)
Lecture 24

NRSC 335 Lecture 24: psychopathology - schizophrenia, depression and OCD
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Department
Neuroscience
Course
NRSC 335
Professor
Stephen Maren
Semester
Spring

Description
Symptoms: Bizarre disturbances in thought Paranoia Grandiose delusions Auditory hallucinations Emotional changes Positive symptoms (abnormal states) Hallucinations, delusions, motor hyperactivity Negative symptoms (insufficient function) Emotional and social withdrawal, impoverishment in thought and speech Genetics High incidence in relatives Heritable Twin studies 60 concordance in monozygotic Both twins have it 12 concordance in dizygotic Both twins have it But identical and fraternal twins are treated differently Adoption studies Eliminates social influence of schizophrenic patients Brains Ventricular enlargement Occurs early in development, maybe prenatal?! Disoriented hippocampal pyramidal cells Viral infection? PET indicates reduced blood flow in frontal cortex During tasks that normally activate the frontal cortex in controls For all pathology, cause and effect? Dopamine Hypothesis Schizophrenia results from too much dopamine in the basal ganglia
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