BIOL 3327 Lecture Notes - Lecture 17: Major Histocompatibility Complex, Mhc Class I, Endoplasmic Reticulum
16 May 2019
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Document Summary
Diseased host cell: host cell infected with virus or bacteria. Altered host cell: neoplastic cells, aging cells, or nonself cells from grafted tissue. Antigenic peptides complexed with class i mhc molecules. Antigen processing takes place in the cytosol by proteasomes. Proteasomes are a multifunctional complex consisting of 28 subunits and having protease activity. Antigenic pieces are transported from cytoplasm to endoplasmic reticulum via transporters associated with antigen processing, tap-1 & tap-2. Tap1 and tap2 form a peptide transporter in the endoplasmic reticulum membrane. Proteasome: cylindrical complex that contains proteolytic activity. Antigenic peptides bind to class i mhc in the rough endoplasmic reticulum. The class i mhc-peptide complex is then transported via the golgi to the cell surface. Pinocytosis; the internalization of extracellular fluid, and anything that fluid contains. Receptor-mediated endocytosis; the internalization of molecules bound to cell surface receptors. Antigenic peptides complexed with class ii mhc molecules.
