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BIO-0013 (103)
Mc Vey (25)
Lecture

11-26-12.docx

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Department
Biology
Course
BIO-0013
Professor
Mc Vey
Semester
Fall

Description
11­26­12 • How do E.coli use glucose over lactose as a food source when BOTH are  available? o Cells must be able to determine if glucose is available o Catabolite repression of the lac operon  Presence of glucose suppresses production of B­galactosidase • cAMP is synthesized when glucose levels are low o glucose inhibits adenylyl cyclase from breaking ATP into Cyclic AMP  (cAMP) and 2 Phosphate groups  cyclic adenosine monophosphate • catabolite activator protein site (CAP) = another regulatory element o in DNA o CAP site is located just upstream from the promoter o cAMP binds to CAP and transcription begins  lots of cAMP  low glucose  transcription occurs rapidly  cannot bind CAP DNA site unless bound to cAMP  allosteric protein (has a shape change) o if cells lack cAMP  high glucose  CAP doesn’t bind to DNA  Transcription occurs slowly o Amount of cAMP and rate of transcription of lac operon are inversely  relat
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