BIO 211 Lecture Notes - Lecture 12: Hemoglobin, Haldane Effect, Ferrous
1 Dec 2020
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One haemoglobin molecule can carry up to 4 o2. Oxyhaemoglobin (hbo2) o2 bound to haemoglobin. Deoxyhaemoglobin (hhb) haemoglobin with no o2. Factors affect the hb affinity are ph, pco2, temperature and 2,3- Carbon monoxide competes for the o2 binding sites on the haemoglobin molecule. Carboxyhaemoglobin co binds to ferrous ion of haemoglobin. The shape of the curve results from the interaction of bound oxygen molecules with incoming molecules. The binding of the first molecule is difficult. Partial pressure of oxygen (pao2) measures the pressure of oxygen dissolved in the blood and how well the oxygen is able to move from the airspace of the lungs into the blood. Partial pressure of carbon dioxide (paco2) this measures how much carbon dioxide is dissolved in the blood and how well carbon dioxide is able to move out of the body. Haemoglobin unloads o2 to match metabolic needs of different states of activity of the tissues some need more, other tissues need less.
