BSC 300 Lecture Notes - Lecture 4: Hsp70, Atp Hydrolysis, Transmissible Spongiform Encephalopathy
18 Apr 2018
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Document Summary
Information for sequence encoded in dna: protein function- derived from 3d structure, which is determined by the amino acid sequence and intramolecular noncovalent interactions. Stable spatial arrangements of polypeptide chain segments held together by hydrogen bonds between backbone amide and carbonyl groups: hydrogen bonds between adjacent amino acids determine secondary structure of protein, tertiary structure- peptide three-dimensional shape. Structure of a peptide composed of secondary structural elements and various loops and turns: may form distinct, independently stable domains, tertiary structure is the conformation of the entire polymer. Functional domain- region of protein that exhibits a specific activity, usually independent of other regions of the protein. Some functional proteins are composed of more than one polypeptide: quaternary structure refers to proteins composed of subunits. It refers to the manner in which subunit interact: protein-protein interactions, different proteins can become physically associated to form a multiprotein or supramolecular complex. Integral membrane proteins- embedded within the phospholipid bilayer of membranes.
