BSC 422 Lecture Notes - Lecture 3: Cytokinesis, Telophase, Fibronectin

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 422
• Professor: Katrina Ramonell

Document Summary

Invasion and metastasis: contact inhibition, tissues have a regular order to the cells. Grow to a specific size and then either divide or stop growing. This is regulated by contact with the next cell: anchorage dependence, the basal lamina is a tough layer with collagen and keratin. If a cell is free floating, cell is signaled for apoptosis. Independence from outside growth factors: stretch receptors signal the cell to stop growing, in cancer cells, you obtain independence from outside growth factors. Grow and divide as they please, don"t depend on or respond to normal growth factors. Insensitivity from antigrowth signals: growth inhibition, cancers at earlier stages respond better to normal cell signals compared to later tumors. They also don"t care about glucose and oxygen levels: some cancer cells are able to recruit glucose to themselves, differentiation, depends more on cell types.