BSC 431 Lecture Notes - Lecture 23: Mycobacterium Bovis, Clofazimine, Nocardia
22 Mar 2016
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Document Summary
Humans are the only natural reservoir for this intracellular pathogen. Tb is the leading cause of death in the world from bacterial infectious disease. Roughly 1/3 of the world population is infected (cdc) 1. 3 million deaths in 2012 (cdc) and 9 million cases worldwide in. In us, tb is on the decline since 1992. Also going down in people co-infected w/ hiv. Most new cases (66%) in us are from foreign born people. Primary infection: micro droplets enter the lung. Vigorous cell mediated immune response causes much of the resulting damage: tubercles form (collection of cells surrounded by activated macrophages) At this stage the individual has tb infection, not tuberculosis. These lesions heal" and are surrounded by fibrin and calcified (easily seen via x-ray) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Close contact w/ lots of people (health care workers, prisoners, etc) The disease that is commonly known as tb is a secondary infection.
