BSC 444 Lecture Notes - Lecture 11: Nuclear Pore, Aciclovir, On2 Technologies
13 Oct 2017
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Document Summary
Initial infection (usually during childhood) results in varicella (chickenpox) Varicella-zoster virus (vzv: spreads to nerve cells latent infection, reactivation results in zoster (shingles) If initial infection occurs during adolescence or adulthood it can develop into mononucleosis (glandular fever: can immortalize/transform b cells is associated with a number of different lymphomas. Human cytomegalovirus (hcmv: symptoms absent or mild in majority of infections, of those 1%, 7% of the time virus causes damage including small brain size, enlargement. In pregnant women, virus can infect the placenta and the fetus with serious consequences. In us, 1% babies born with hcmv of liver and/or spleen, hearing loss, mental retardation: also causes sever diseases (pneumonitis, hepatitis) in immunocompromised patients (aids, cancer treatments, organ transplant) Hsv-1 virion structure: dsdna linear genome, genome- encodes all viral proteins needed to replicate the virus, capsid- icosahedron, t = 16, 12 pentons, 150 hexons.
