CH 461 Lecture Notes - Lecture 1: Critical Micelle Concentration, Lipid Droplet, Bile Acid

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10 Jul 2018
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Energy production from triacylglycerols starts with their hydrolysis into free fatty acids and glycerol. Enzymes called lipases, which catalyze the reaction, carry out this hydrolysis. The reaction releases the three fatty acids and glycerol. An intestinal carrier absorbs the glycerol, which will eventually rejoin with fatty acids in the intestinal cells. The body must absorb the fatty acids released by the lipases by a rather more involved mechanism. Fatty acids are poorly soluble in water, although they are more soluble than triacylglycerols. Lipids of whatever kind tend to form droplets. Protein enzymes are water soluble and therefore cannot gain easy access to the lipid droplet. To be digested, lipids must be emulsified into small droplets, which have a larger surface area. In other words, the hydrophobic interactions forcing the lipids into larger droplets must be overcome. The molecules that carry out this function are called bile salts or bile acids.

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