CH 461 Lecture Notes - Lecture 21: Pteridine, Purine Metabolism, Pyrazine
Document Summary
The 1 carbon transformations require two cofactors especially: folic acid and vitamin. Several compounds that interfere with folic acid metabolism are used in clinical medicine as inhibitors of cancer cells or bacterial growth. Folic acid participates in the activation of single carbons and in the oxidation and amino acid metabolism and in biosynthetic pathways leading to dna, rna, membrane lipids, and neurotransmitters. Folic acid is a composite molecule, being made up of three parts: a pteridine ring aminobenzoic acid portion participate directly in the metabolic reactions of folate. doesn"t participate in the coenzyme functions of folic acid. Instead, folic acid in the interior of the cell may contain a (cid:1688)chain(cid:1689) of three to eight (1 6) glutamic acids, which serves as a negatively charged (cid:1688)handle(cid:1689) to keep the coenzyme inside cells and/or reduction of single carbons. Folate dependent single carbon reactions are important in system (6 methylpterin), para aminobenzoic acid, and glutamic acid.
