BIO 201 Lecture Notes - Lecture 14: Autocrine Signalling, Cell Signaling, Cyclic Adenosine Monophosphate

• School: University at Buffalo
• Department: Biological Sciences
• Course: BIO 201
• Professor: Lara Hutson

Document Summary

Cells must be able to respond to signals from both outside a(cid:374)d i(cid:374)side the orga(cid:374)is(cid:373) their response should benefit the organism or the population. The signal itself (a. k. a. ligand(cid:895) is produ(cid:272)ed (cid:271)y a (cid:862)se(cid:374)der(cid:863) a(cid:374)d re(cid:272)ei(cid:448)ed (cid:271)y a (cid:862)re(cid:272)ipie(cid:374)t. (cid:863) ig(cid:374)ali(cid:374)g (cid:373)odes are defi(cid:374)ed (cid:271)y dista(cid:374)(cid:272)e (cid:271)et(cid:449)ee(cid:374) (cid:862)se(cid:374)der(cid:863) a(cid:374)d (cid:862)re(cid:272)ipie(cid:374)t(cid:863: autocrine. Autocrine (cid:862) e(cid:374)der(cid:863) a(cid:374)d (cid:862)re(cid:272)ipie(cid:374)t(cid:863) are the sa(cid:373)e (cid:272)ell or group of (cid:272)ells. A single signaling cell receives a weak autocrine signal. In a group of identical signaling cells, each cell receives a strong autocrine signal. Signaling molecule is attached to sender cell or is part of ecm; does not diffuse. Signaling molecule can diffuse one or several cell diameters away to nearby recipient cells advantages: communication with more cells than juxtacrine; moderately fast. Disadvantages: not as precise as juxtacrine; still fairly short-range. Signaling molecule (hormone) is secreted into the bloodstream, allowing it to diffuse throughout body. Disadvantages: very little septicity; relatively slow because you have to wait for the.