BSCI 283 Lecture Notes - Lecture 17: Virulence Factor, Teichoic Acid, Polysaccharide
12 Apr 2017
School
Department
Course
Professor
Document Summary
Restrictions to bacterial growth: water- limiting factor for growth on skin, iron-limiting factor for intestinal growth restrict trace elements, stationary phase growth does not occur in nature, always in exponential phase but with generation time, critical: nutrient depletion/toxin accumulation. Restrictions to human microbiome: skin-dead skin cells no water, stomach- too high ph, when going from one environment to another can be harmful, normal flora compete with pathogens for nutrients. Benefits of normal microbiota: gnotobiotic- germ free animals. Requirement for vitamins (k and b: some bacteria can cause disease sometimes, but most microbes do not, and many are beneficial to humans. Must have genetic material to create capsule. Other proteins beside capsule can secrete enzymes which cause cells to lyse. Characteristics of pathogen: obligate, opportunistic, able to cause disease. Perturbation from normal (arrange of a subjective measure that pertains to the individual) Infectious diseases: establish that bacterium causes disease. Host-pathogen interaction: health is balance between human contributions and bacterial contributions, human.
