BSCI 223 Lecture Notes - Lecture 24: Memory T Cell, History Of China, Vaccinia
3 May 2016
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Natural, passive (mother can transfer antibodies to child before birth- so when really young, the child has the mother"s antibodies and then when they are born, they develop a little more) Passive- do not have memory, don"t develop it themselves. Injected vaccine (salk); first, less effective but contains dead virulent virus. No risk of infection, but manufacturing uses deadly form: oral vaccine (sabin); most effective but contains live virus (attenuated), cheaper. B cells: each responds to specific epitope of antigen (b-cell receptor; antibody, plasma cells- produce abs, memory b cells. T cells: each responds to specific epitope of antigen (t-cell receptor; tcr) presented by. Mhc (class i or ii: cytotoxic t cells (tc); cd8 kill infected host cells secrete toxins (e. g. , perforins, helper t cells (th); cd4 secrete cytokines. Help activate b cells and macrophages: memory t cells long-lived, ready, quick. Vaccine: comes from jenner (1796) using cowpox (vaccinia virus) to prevent the human viral disease smallpox.
