BIL 150 Lecture Notes - Lecture 24: Nonsense Mutation, Mutation, Missense Mutation

• School: University of Miami
• Department: Biology
• Course: BIL 150
• Professor: Malancha

Document Summary

Termination of transcription: different in bacteria and eukaryotes. In bacteria, the polymerase stops transcription at the end of the terminator and the mrna can be translated without modification. In eukaryotes, rna polymerase ii transcribes the polyadenylation signal sequence; the rna transcript is released 10-35 nucleotides past this polyadenylation sequence. Introns: long noncoding stretches of nucleotides that lie between: exons, rna splicing, carried out by by spliceosomes, a variety of proteins and small nuclear ribonucleoproteins (snrnps) that recognize splice sites, they also catalyze the splicing reaction. Alternative splicing: developmental and tissue specific splice forms. Molecular components of translation: a cell translates an mrna message into protein with the help of transfer rna (trna) trna transfers amino acids to the growing polypeptide in a ribosome. Ribosomes: facilitate with specific coupling of trna anticodons with mrna codons in protein synthesis, 2 complexes large and small. Protein folding: polypeptide chain starts to coil.