BIL 250 Lecture Notes - Lecture 1: Missense Mutation, List Of Rabbit Breeds, Nonsense Mutation

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Deletions or insertions of one ore more base pairs. Mutations may occur within the coding or noncoding regions of an gene. May or may not bring about detectable changes in phenotype. Spontaneous mutations happen naturally and randomly and are usually linked to normal biological or chemical processes in the organism that alters the structure of nitrogenous bases. Often occur during the enzymatic process of dna replication. Induced mutations result from the influence of an extraneous factor, either natural or artificial. The rate of mutation (the likelihood that a gene will undergo a mutation in a single generation or in forming a single gamete) is exceedingly low for all organisms. Humans and drosophila have higher mutation rates that neurospora, viruses, and bacteria. Even within the same species the spontaneous mutation rate varies from gene to gene. Somatic mutations: occur in any cell except germ cells and are not heritable. Germ-line mutations: occur in gametes and are inherited.

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