BMB 401 Lecture Notes - Lecture 6: Insulin Receptor, Glucagon, Trypsin

• School: University of Miami
• Department: Biochemistry and Molecular Biology
• Course: BMB 401
• Professor: Farooq

Document Summary

Micromolecular hormones small molecules like steroid hormones. Macromolecular hormones like insulin and glucagon: glands are specialized organs that make stuff. Exocrine = secrete stuff through ducts (sweat, salivary, mammary) Endocrine = ductless and stuff goes straight into bloodstream (pituitary, thyroid: pancreas gland can be exocrine and endocrine. Islets of langerhans (2%) secrete insulin and glucagon into bloodstream. Reme(cid:373)(cid:271)er steroid hor(cid:373)o(cid:374)es do(cid:374)"t (cid:374)eed re(cid:272)eptor because they can diffuse through membrane and find target receptors in the cell: all come from backbone of cholesterol, re(cid:448)ie(cid:449) slide (cid:449)as(cid:374)"t payi(cid:374)g atte(cid:374)tio(cid:374) Insulin and glucagon regulate blood sugar level (insulin helps glucose absorption from blood to cells) 10 re(cid:448)ie(cid:449) si(cid:374)(cid:272)e (cid:449)as(cid:374)"t payi(cid:374)g atte(cid:374)tio(cid:374) (cid:373)u(cid:272)h: hormone receptors mediate extracellular signals at the cell surface to downstream targets like transcription factors in nucleus downstream, 3 categories: rtks, gpcrs and shrs. Db (dna binding) domain = binds to promoters of target genes. Lb (ligand binding) domain = binds ligand and activates protein.