MIC 301 Lecture Notes - Lecture 8: Cholera Toxin, Eef2, Diphtheria Toxin

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 301
• Professor: Williams Roger

Document Summary

Proteins that produce massive cellular immune response that can lead to fatal shock. Some of the pathogens are opportunistic and get in through cuts and stuff like that. Mechanism: stimulate t cells, massive induction of pro inflammatory cytokines. 4: present antigen on mhc-ii and it gets recognized by t cell receptor (tcr, stimulates small subclass of t cells. Superantigens bypass this mechanism altogether (right on slide: no longer need this precise lock and key between mch-ii and tcr, activates large # of t cells. Superantigens bypass antigen specificity usually needed to stimulate 80-90% t cells and create a big response. Slide 6: nad split then adp ribose broken off, adp ribose is going to be broken in half and then it will be added to substrate (something in our cells) Cholera toxin takes the ribose off and attach it to regulatory protein. 9: secretion across om is type 2 secretions.