MIC 321 Lecture Notes - Lecture 5: B-Cell Receptor, Stromal Cell, Neprilysin

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 321
• Professor: Williams Roger

Document Summary

B cell precursors come from stem cells: cd10 and cd34 are lymphoid progenitors, once in pro cell form, no going back, slide 4 shows them going through stem cell stage up to pro b cell stage. 6: earliest event is dj heavy rearrangement. Stromal cells in bone marrow: scf (stem cell factor) and its receptor kit. Initiate expression of new transcription factors for making protein to take it to next stage in development: 1st cytokine in development of b cell is il7 expression. Stops vdj for a little to allow cell to undergo cell cycle. 7 - pro b cell of heavy chain: 2 chromosomes so some make rearrangements that are functional genes and other ones makes one that isn"t and goes to die. Only express 1 allele (1 receptor maintained only: if first is good, keep it. If bad, go to second and only keep that one. Slide 11 shows allelic exclusion gives better specificity.