MIC 321 Lecture Notes - Lecture 12: T Helper Cell, Hematopoietic Stem Cell Transplantation, Cytotoxic T Cell

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 321
• Professor: Williams Roger

Document Summary

Understand what goes in the thymus and what comes out . Thymic progenitors (etps) are cells not yet fully committed to becoming t cells: become fully committing into thymus after leaving bone marrow, still have potential to become nk cell if you removed them. Regulatory cell that negatively controls activity against antigens. Recognize phospholipids/proteins instead of peptides like normal t cells. We call them t cells because they rearrange tcr: definition for a t cell. Phenotype of mice and humans lacking a thymus compared to those lacking functional precursor cells. Thymus develops from a pouch: 3rd pouch develops from tbx1 (transcription factor) Thymic epithelial cells (tecs) from sophisticated travel niches for developing thymocytes. Tec"s talk to developing thymocytes to allow them to mature tecs and t cells: made possible by foxn1. If have defect for thymocyte = can"t talk back to tec and they don"t develop properly. If have tec issue, won"t work and so thymocyte will become dysfunctional.