MIC 323 Lecture Notes - Lecture 7: Phase Variation, Neisseria, Antigenic Variation
29 Nov 2016
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2 neisseria: gram and exists in these circular pairs (diplococci) Most of them have something to do with surface molecules (pili, enzymes that put sugars on lps: we find 2 forms for these genes. One has 1 repeat and other has 2 repeats. Repeats is 11 (not a multiple of 3 (codon)) Means both of them have different reading frames because it has been altered by this addition of 11 so this has altered the downstream reading frame. In this gene the top one is functional gene for a functional pilus. 3 ways: take advantage of the inhibitor factors. Stuff around the host factors in pic are bacterial factors to exploit the host factors: 1 = porins are outer membrane proteins that bind complement factors and. Neisseria pora on outer membrane and c4b recruits c4bp (c4 binding protein) to compete for binding and prevent complement binding.
