MIC 323 Lecture Notes - Lecture 18: Neutrophil, Septicemic Plague, Pneumonic Plague

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 323
• Professor: Schesser Kurt

Document Summary

Picked this up last few 1000 years = emerging disease: get infection and if stays local call it bubonic plague. If immune system cannot contain local infection and gets into circulatory system. If gets into lungs even worse with death and called pneumonic plague and now it can be transmitted through aerosols. Infected rodent bitten by a flea (around 5000 bacteria) likely flea gets infected: once pathogen gains access to fleas super infection!! Identified some orfs and knocked them out: nhs = normal human serum not been heated up (this kills complement) 6 lps: lps activates toll, makes different lps form at 37 degrees which is on left and is tlr4 antagonist and so when grown at our temp induces less tlr than normal. 7 t3ss/yope: (cid:1011) (cid:454) (cid:1005)(cid:1004)^4 is s(cid:373)all so it(cid:859)s a(cid:374) e(cid:454)tra (cid:272)hro(cid:373)oso(cid:373)al plas(cid:373)id (cid:894)ge(cid:374)o(cid:373)e 4(cid:454)(cid:1005)(cid:1004)^(cid:1010) (cid:271)p(cid:895) Lecture 18: pathogenicity island b/c find genes on bottom and bottom right blocks encode.