MIC 323 Lecture Notes - Lecture 2: Intracellular Parasite, Listeria, N-Terminus

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 323
• Professor: Schesser Kurt

Document Summary

6: lister was famous surgeon in england, gram + rods, very good in very different environments. Problem in food industry because can grow relatively well at 4 celsius (refrigeration temperature) Seems to compete well in food processing plants with other bacteria. Invade, escape and motor around: listeria mediated by separate independent virulence factors, also nice because easily modifiable, will now discuss each of three steps in detail. 7 internalization step: has 2 invasins and these bind receptors like normal receptors, cell is tricked into internalizing receptor and gets dragged into cell, listeria activates normal process and goes along for the ride. Lecture 2: red part is domain that actually binds to surface, what does red domain bind too?! E-cadherin: this receptor normally functions as glue b/w tight junctions, type of binding is mediated by the inla covalently attached to listeria outer surface.