CHEM 1103 Lecture Notes - Lecture 41: Reactive Oxygen Species, Glutathione, Phosphorylation
1 Mar 2019
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Lecture 41: reactive oxygen species: oxidative phosphorylation and r. Reactive oxygen species (ros: are unstable derivatives formed when oxygen picks up a single electron (e-, these molecules can damage cells if they are allowed to accumulate in the cell. Oxidative stress and oxidative damage: types of oxidative damage include (but not limited to), enzyme inactivation, polysaccharide depolymerization, dna breakage, and membrane destruction (lipid oxidation, types of events that can lead to oxidative stress include: Superoxide can react with h+ to form peroxide: Peroxide has limited reactivity, but it can react with fe2+ Hydroxyl radical: hydroxyl radicals can generate a series of. Autocatalytic events and modify cellular molecules (especially lipids: this becomes a chain reaction in the presence of a transition metal (here fe) and can cause breaks in lipids. Singlet oxygen: singlet oxygen, 1o2, can be formed from superoxide or from peroxides. An unpaired electron absorbs energy and shifts to a higher electron orbital (giving it a higher energy state)
