BIOLOGY 3UU3 Chapter Notes - Chapter 18: Catenin, Haploinsufficiency, P21
13 Apr 2017
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Forkhead homeobox type o transcription factors in the response to oxidative. Cellular sensing of oxidative stress (cid:120) ros sensing signaling molecules activated where ros is generated. Src-intiated signaling pathway is induced to promote survival of cancer cells. (cid:131) src has cysteine residue motif that activates kinases of nk-kb by direct oxidation. (cid:120) foxo transcription factors: regulated by h2o2, sense cellular redox state. Induce apoptosis, stress resistance, or senescence. (cid:120) foxo4 regulated by cellular redox through: monoubiquitination or, Induction of cysteine thiol disulfide dependent complexes of foxo with acetyltransferase/creb binding protein. (cid:120) binding of p300/cbp to foxo for foxo mediated transcription: cbp and p300 = foxo cofactors; weaken histone/dna interactions. Implications of extending lifespan and preventing ros initiated diseases by inhibiting and modulating ros sensing signaling molecules. Increase in oxidants responsible for >40 human diseases (i. e. parkinson"s and alzheimer"s). (cid:120) (cid:120) aging and age related diseases dependent on rates of ros detoxification/generation and replacement of oxidative damaged macromolecules over time.
