CHEM 3050 Lecture Notes - Lecture 3: Dna Adduct, Green Chemistry, Stereochemistry
Document Summary
), developmental (for small children), neurotoxicity, mutagenicity (change of dna, mutations), narcosis, carcinogenicity, biochemical/molecular (small molecule transformation in organisms), behavioral: mechanisms of action of chemicals. Narcosis: generalized depression in biological activity, due to presence of toxicant in cell membranes (anesthesia, alcohol intoxication): reversible. Risk assessment and management- 4 phases: hazard evaluation, exposure and effects assessment, risk characterization, risk management. Toxicology provides hazard data that can be leveraged to inform green chemistry initiatives to achieve preferred manufacturing processes and products. Hazard determination and risk evaluation are broadly utilized in industry for product development and approval. If more than 3 halogens in molecule, it will reduce biodegradability and will last longer in environment: qsar / computational methods, short term assay/surrogate test. In vivo test: us epa had ecosar. Actor database: approaches to designing chemicals of reduced hazard if you know a structure motif will cause cancer, avoid that structure similarity.
