PCL102H1 Lecture Notes - Lecture 20: Hepatotoxicity, Botulinum Toxin, Serum (Blood)
17 Mar 2016
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Drugs often fail in late stage clinical trials: due to adverse side effects, not predicted outcome and $ Identifying and the dose-limiting toxicity of lead compounds before they are tested in clinical trials is an essential part of drug development. Exaggerating the dose and the duration of the exposure (relative to the intended clinical use) Time involved: chronic exposure in animal models (6 months to a year: one rodent species and one non rodent species, look back at slide 4. Toxicology is the study of adverse effects of chemicals on living organism. Toxicology research focuses on mechanism of actions: cellular, biochemical, molecular and functional: neurobehavioral, immunological. Also acute (quick) vs. chronic (long term) effects. Toxicologist are people who discover and describe how reduce exposures, ways to use chemicals and drugs safely. Quantitative assessment of the risk and adverse effects (hazard exposure combined)
