BIO 479 Lecture Notes - Lecture 8: Adrenal Gland, Zona Fasciculata, Zona Glomerulosa
22 Mar 2018
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Sunday, february (cid:400)(cid:400), (cid:401)(cid:399)(cid:400)8 9:(cid:403)6 pm: naturally occurring steroirds: Cholesterol a precursor for steroid hormones: (cid:401)7 carbons. Vitamin d a calcium absorption regulator in the gut: for bones and muscles , nerve cells in bones, (cid:401)(cid:404) carbons, adrenocortical steroids cortisol, corticosterone, aldosterone. As mineralocorticosteroids regulate sodium and potassium flux in the kidney (cid:336)water balance(cid:337) Carbon provides usual tetrahedral shape but shape varies due to single and double bonds and triple bonds. On planar surface, bonds projecting away = alpha Enzymes can rotate the bonds to quickly make inactive forms active and vice versa; usually at carbons (cid:402),(cid:404),(cid:400)(cid:400), or (cid:400)7: steroid synthesis: Cholesterol: made in liver or can eat, (cid:401)7 carbons, (cid:401) carbons attached to carbon (cid:400)(cid:402) and (cid:400)(cid:399, packaged with water-soluble lipoprotein, soluble in plasma to reach various steroidogenic tissues. Ldl low density lipoprotein, hdl = high density ; carrier proteins.
