BIO 253 Lecture Notes - Lecture 10: Lysine, Electrophile, Acetyl Group
Document Summary
Zymogen activation: make protein and then activate it later so that it can work later. Which side chains will be reactive: side chains with a lot of carbons and hydrogens are not as reactive whereas side chains with oh groups are more reactive. What are biology groups that are transferred to other molecules: such as methyl groups, acetyl groups and phosphate groups. Phosphate group: can more partial double bond character in which the negative charge flows all around the molecule. Oxygen is much more electronegative than phosphorus and which makes the phosphorus much more polar positive charge and can serve as an electrophile (in which a nucleophile can come in and attack) **even though this reaction happens spontaneous, it does not mean that the rate of reaction happens very fast or even in your lifetime. **you can use histidine, arginine, lysine amino acids. Kinases catalyze phosphorylation: some basic residue and acidic residue that interact with each other.
