BIOL 134 Lecture Notes - Lecture 19: Jules Bordet, Innate Immune System, Adaptive Immune System

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26 Oct 2016
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The innate immune system is a hereditary defensive system. Factors found in the blood that attack bacteria. Name comes from its discovery: jules bordet (1896) Discovered 2 factors (in plasma) that killed bacteria: Complement refers to a system of over 30 proteins found in the blood. Defensive network set off by 2 different signals: antibodies: reacts to presence of multiple antibodies bound to a surface (adaptive immunity, foreign surfaces: has proteins that recognize certain characteristic bacterial proteins/carbohydrates. The targeting of complement to foreign surfaces in in place at birth and never changes. Non-host molecules that are commonly associated with pathogens. Receptors for recognition of pamps are present at birth as a key part of the innate immune system. Proteins near pamps get more immune exposure and are more likely to develop an adaptive immune response too! Effects: opsonization: coating of an object with immune system proteins, phagocytosis, cytolysis: punches holes in the plasma membrane, lyses cells.

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